Ectopeptidases are transmembrane proteins present in a wide variety of tissues and cell types. Dysregulated expression of certain ectopeptidases in human malignancies suggests their value as clinical markers. Ectopeptidase interaction with agonistic antibodies or their inhibitors has revealed that these ectoenzymes are able to modulate bioactive peptide responses and to influence growth, apoptosis and differentiation, as well as adhesion and motility, all functions involved in normal and tumoral processes. There is evidence that ectopeptidase-mediated signal transduction frequently involves tyrosine phosphorylation. Combined (...) analyses of gene organization and regulation of ectopeptidases by various physiological factors have provided insights into their structure–function relationships. Understanding the roles of ectopeptidases in pathophysiology may have implications in considering them as therapeutic targets. BioEssays 23:251–260, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Quelle est la nature et la fonction des sentiments dans l’activité de connaissance et, plus largement, dans l’existence humaine? Cette question, massive, n’a cessé d’inquiéter la philosophie, dont l’histoire paraît à bien des égards se confondre avec celle d’une opposition entre la lucidité de la raison et l’obscurité dangereuse des passions. Si le discours philosophique n’a jamais nié l’importance des sentiments, ni leur rôle dans l’ordonnancement général de la vie humaine, ce discours est cependant empreint d’ambiguïtés, comme l’est, déjà, le (...) statut du « cœur » dans la tripartition fonctionnelle de l’âme présentée par Platon : ni réductible à la droite raison, ni relégué dans la sphère des désirs qui nous empêchent de contempler les Idées, le sentiment est cet intermédiaire allié de la raison qui met en mouvement nos réactions morales. Cette ambiguïté se retrouve à l’âge classique, lorsque le discours philosophique découvre le fonctionnement des passions et cherche les modèles scientifiques susceptibles d’en rendre compte, hésitant entre la physiologie , la géométrie , la médecine et les sciences de la nature .En faisant de l’affectivité l’une des structures fondamentales de l’existence, la phénoménologie a replacé au centre du questionnement philosophique la problématique des sentiments. Mais comment décrire ces expériences singulières – celle de l’amour, de l’angoisse, du désespoir ou de la joie – sans les confondre avec des objets? Comment donner du sens aux affects sans adopter ce point de vue surplombant des sciences de la nature, qui confond le discours des causes et celui des raisons? Comment, en d’autres termes, continuer à parler des sentiments de manière raisonnée, tout en reconnaissant que les sentiments nous font autant que nous les connaissons – tout en continuant, par conséquent, à être réceptifs à leur pouvoir de nous ébranler? (shrink)

To deal with the upcoming challenges and complexity of the nursing profession, it is deemed important to reflect on our current organization of care. However, before starting to rethink the organization of nursing care, an overview of important elements concerning nursing care organization, more specifically nursing models, is necessary. The aim of this study was to conduct a mapping review, accompanied by an evidence map to map the existing literature, to map the field of knowledge on a meta‐level and to (...) identify current research gaps concerning nursing models in a hospital setting. Next to nursing models, two other organizational correlates seem to be of importance when looking at the organization of nursing care: nurse staffing and skill mix. Although it seems that in recent research, the theoretical focus on the organization of nursing care has been left behind, the increasingly complex healthcare environment might gain from the use of nursing theory, or in this case, care delivery models. As almost no fundamental studies have been done toward the combination of care delivery models, nurse staffing, and skill mix, those elements should be taken into account to fully capture the organization of nursing care in future research. (shrink)

O presente artigo busca tecer algumas considerações sobre o desenvolvimento do Subprojeto de pesquisa Formação instaurando competência que visa verificar como os processos de formação, dado ao contexto sócio-econômico atual, estão-se organizando quanto à construção da competência, demanda recente do mundo do trabalho.

Evaluative conditioning (EC) is one of the terms that is used to refer to associatively induced changes in liking. Many controversies have arisen in the literature on EC. Do associatively induced changes in liking actually exist? Does EC depend on awareness of the fact that stimuli are associated? Is EC resistant to extinction? Does attention help or hinder EC? As an introduction to this special issue, we will discuss the extent to which the papers that are published in this issue (...) help to resolve some of the controversies that surround EC. We also speculate about possible boundary conditions of EC and attempt to reconcile conflicting results on the functional properties of EC. (shrink)

edited by Ciaran Cronin and Pablo De Greiff Since its appearance in English translation in 1996, Jürgen Habermas's Between Facts and Norms has become the focus of a productive dialogue between German and Anglo-American legal and political theorists. The present volume contains ten essays that provide an overview of Habermas's political thought since the original appearance of Between Facts and Norms in 1992 and extend his model of deliberative democracy in novel ways to issues untreated in the earlier work.Habermas's theory (...) of democracy has at least three features that set it apart from competing positions. First, it combines a concern with questions of normative justification with an empirical analysis of the social conditions necessary for the realization of democratic institutions. Second, at the heart of his model is the assertion of an internal relationship between liberalism and democracy. On this account, the rights of the individual that are central to liberalism can be guaranteed only within a constitutional framework that at the same time fosters democratic rights of political participation through the public sphere. Finally, Habermas defends a conception of universal human rights that is not only sensitive to cultural differences but also calls for legal and political institutions that facilitate the cultivation of cultural and religious identities within pluralistic societies.These essays demonstrate the extraordinary power of Habermas's theory of democracy through a further engagement with Rawls's political liberalism and through original contributions to current debates over nationalism, multiculturalism, and the viability of supranational political institutions. (shrink)

In disproof of the materialist principle, that common things exist unperceived, and in defence of the New Principle, Philonous here objects that it is inconceivable that a common thing should do so. Hylas replies that, on the contrary, we can and do think of, e.g., a tree standing alone as opposed to a tree being perceived by an observer. But Philonous counter-objects to this reply that it contains a contradiction, since it asserts that we can think of something which is (...) not thought of. (shrink)